Scientifically Proven Health Benefits of FlexC PRO EX

Joint Health and Function

Bone Health

Muscle Health

Skin Health

Hair and Nail Health

Joint Health and Function

FlexC PRO EX supports overall joint health and slows down the effects of ageing on joints by

i) Providing instant collagen “top-up” with complete Peptan® type I, II, III collagen peptides.  Collagen is the main protein that makes up our ligaments, joints and muscles, and provides our bodies with structural support.

ii) Targeting inflammation with Curcumin C3 Reduct® Tetrahydrocurcuminoids. Inflammation causes joint swelling, pain and stiffness. When left untreated, inflammation may attack the joint tissues and cause further joint swelling, cartilage & bone damage and muscle loss.

iii) Rebuilding joints and collagen with Silica-Rx99®. Touted as a collagen booster, silica is vital for maintaining healthy connective tissue. By stimulating collagen synthesis from the root, Silica-Rx99® offers a long-lasting solution for optimal collagen production.

1.1) Relieve pain and stiffness

Pain and stiffness are primary factors that result in limited mobility and difficulty in performing daily tasks. It is also responsible for the decline in the quality of life for people with knee osteoarthritis (OA). New survey results have suggested that osteoarthritis negatively affects physical as well as mental health.

Results show the health-related quality of life of people with arthritis was two to three times worse than people without it.

Study 1:

Peptan® Collagen Peptides can effectively help improve joint stiffness and reduce joint swelling. 94 women aged 40 to 70 with knee joint problems (Osteoarthritis) were administered 8g of Peptan® or placebo daily for a period of 6 months. Peptan®-treated subjects showed 24% decrease in stiffness and joint pain as reflected in the WOMAC** score

**WOMAC score is the standard international method for clinical assessment of joint health in patients.

Study 2:

Patients suffering from mild-to-moderate knee osteoarthritis (OA) were administered with Curcumin C3 Complex® for 6 weeks. Curcumin C3 Reduct® was derived from Curcumin C3 Complex®.

Significant improvement in pain levels, stiffness and physical function scores were observed, compared to baseline (before treatment). In addition, subjects who reported no or decreased use of NSAIDs (naproxen) at the end of study were significantly greater in the Curcumin C3 Complex® group (p < 0.001), this suggests the effectiveness of curcumin in managing OA.

1.2) Improve joint flexibility

Maintaining flexibility and having full joint mobility is imperative for a good quality of life. Without joint flexibility, daily activities would become more difficult to perform. Muscles become more inflexible, muscle fatigue sets in more quickly and the individual would be more prone to injuries.

Study 1:

A randomised double-blind, placebo- controlled study was conducted on 94 women aged 40 to 70 with osteoarthritis. They were administered 8g of Peptan or placebo daily for a period of 6 months.

The Lysholm score is linked to the improvement of knee movement in everyday activities. Increased score value represents improvement in the condition. Elderly women with osteoarthritis who were given Peptan® for six months and was observed to have improved mobility (higher Lysholm score)

1.3) Reduce joint inflammation

Joint inflammation deters the restorative process of cartilage repair and is also the root cause of joint discomfort. Targeting inflammation is key to breaking the vicious cycle of joint damage and pain and to allow the joint to start healing naturally.

Study 1:

Joint inflammation is a common symptom of osteoarthritis. In an in vivo study, inflammation in the knee significantly reduced with the administration of Peptan®. Furthermore, Peptan®-treated groups also showed significantly lower levels of TNF, a protein that suggests inflammation. These studies provided compelling evidence of Peptan’s® unique capability in reducing joint inflammation.

Study 2:

In this test, subjects with post-traumatic osteoarthritis were administered Peptan® IIm for 3 weeks. Results show increased anti-inflammatory action in the knee joint. This was demonstrated by the reduced local expression of TNF inflammation markers in the synovial membrane.

Peptan® IIm supplementation over 3 weeks also demonstrated efficient protection of the knee joint from local synovial inflammation in obesity-associated osteoarthritis.

The image below shows TNF immunohistochemistry in knee joints of subjects. Brown staining, as highlighted by the arrows, represents inflammation. The staining is apparent for control group, but there is no staining for Peptan® IIm group. Hence, Peptan® IIm protects against local, synovial inflammation in joints of obese animals.

Study 3:

Both curcumin and THC showed potent anti-inflammatory effects at low doses, but the effectiveness of THC is still apparent at a much lower dose. This implies that THC (Curcumin C3 Reduct®) is more effective than curcumin in supporting healthy inflammatory response.

1.4) Stimulate production of cartilage cells

Cartilage is a flexible connective tissue that coats the surfaces of the bones in our joints and cushions the bones against impact. However, cartilage deteriorates naturally with age. This can cause soreness and take a physical toll on the body.

Study 1:

Peptan® Collagen Peptides has been proven to be effective in stimulating cartilage production. The key components of cartilage are collagen and aggrecan. Collagen fibres are responsible for structure and strength while aggrecan serve as a lubricant to the joint.

Study 2:

In an in vitro study, primary cartilage cells (chondrocytes) were cultured in Peptan® for 8 days. Results showed that Peptan® was able to induce the production of primary cartilage cells. Over time, Peptan® treatment has a clear cartilage regenerative effect, with drastic increase in aggrecan production. The cartilage surface is smoother and the number of cartilage cells increaseD after 12 weeks.

1.5) Protect and Lubricate Joints

Joint lubrication helps reduce pain, minimize joint destruction and allow for ease in mobility. Without proper joint lubrication, the bones would rub against each other and this will lead to soreness.

Study 1:

In post-traumatic osteoarthritis, joint injury triggers cartilage loss and inflammation of the knee joint. In this study, subjects with post-traumatic osteoarthritis were administered Peptan® IIm for 3 months. Peptan® IIm was shown to help protect the cartilage from further deterioration, as illustrated by the increased cartilage area. Peptan® IIm also improves lubrication via the stimulation of proteoglycan production in cartilage cells, as shown by an increase in % of active cells.

Study 2:

Similar protective effects was also observed on a model for obesity-associated osteoarthritis combined with injury. Peptan® IIm supplementation for 3 weeks helped protect cartilage (as shown by an increase of cartilage area) and lubricate the joint (as shown by an increase in % of active cells).

1.6) Provide antioxidant protection

Besides “mechanical stress”, oxidative stress also contributes to the development and progression of osteoarthritis (OA). Antioxidant protection helps reduce cartilage damage, thereby reducing pain and inflammation.

Study 1:

Tetrahydrocurcumin (THC) is a powerful antioxidant that helps prevent formation of free radicals and quench pre-formed free radicals into non-free radical form. Research has also shown that THC has higher antioxidant activity than vitamin C (commonly used antioxidant) and curcumin.

Bone Health

Collagen is the main protein in bone, it makes up more than 90% of organic bone mass and provides the structural framework for mineral deposition. By forming long fibres, collagen provides strength and flexibility to the bones, helping to resist bone fractures.

2.1) Restore Bone Mineral Density and Strengthen Bone

Low bone mass is prevalent with age. Fracture risk is higher in the wrist, hip, and spine. These fractures can severely affect mobility and independence. There has always been a popular preconceived notion that osteoporosis is an inevitable part of aging. However, replenishment with the right nutrients, particularly Silica-Rx99®, helps protect the bones and decrease the chances of getting osteoporosis.

Study 1:

Low bone mineral density results when bone resorption (transfer of calcium from bone tissue to the blood) exceeds bone formation. Peptan® Collagen Peptides helps restore bone mineral density and reduce the risk of osteoporosis.

Study 2:

In a monitoring test, 8 women aged between 45 and 82 years old and one man aged 58 years old were administered Silica-Rx99® (≥ 40mg silicon) daily for 6 months and their bone density was monitored. Surprisingly, all 9 participants showed an increase in bone density (100% efficacy). On average, bone density had increased by 13%. This includes postmenopausal women. Notably, Silica-Rx99® worked 4 to 6 times faster than a specific calcium supplement for all 9 participants. In this test, one participant was suffering from osteoporosis and her bone density kept decreasing despite taking prescribed drugs. Yet, her bone density increased after taking Silica-Rx99®. Besides Silica-Rx99®, there is no other silica products that has shown such dramatic improvement in bone density in such a short period of time. These groundbreaking findings have been published in Nippon Dental Newspaper and Medical Magazine Apolonia.

2.2) Stimulate Formation of Osteoblasts (bone-forming cells)

Osteoblasts are the cells that form new bone, which is made of bone collagen and minerals. With age, the rate of new bone formation does not catch up to the rate of bone resorption. This will lead to bone loss, reduced bone mass and increased fracture risk.

Study 1:

An in vitro study showed that Peptan® treatment supports the formation of bone-forming cells (osteoblasts) and stimulates activity while suppressing the bone-resorbing cells (osteoclasts). Hence, osteoclasts cannot develop into mature and fully functional cells that break down bone mass. The control protein (BSA) cannot demonstrate the same effect.

Study 2:

To assess this efficacy on humans, 10 healthy volunteers fasted for 12 hours and were administered with 25g Peptan® collagen peptides or 25g hydrolysed casein dissolved in water. Results confirmed that collagen-enriched blood serum helped increase osteoblast activity, support bone formation and decrease osteoclastogenesis, which is responsible for the degradation of bone cells.

Muscle Health

Sarcopenia – the loss of muscle mass and function is a common concern that comes with age. Strong muscles are important as it attaches to bones and facilitates mobility and movement. They also help to keep joints in the correct alignment. Peptan® Collagen Peptides and Silica-Rx99® are beneficial for preserving lean body mass and supporting muscle tissue recovery.

3.1) Strengthen Tendon

Tendon is a connective tissue that connects muscle to bone and is capable of withstanding tension. With age, tendons become stiffer, weaker and more prone toward injury, leading to a snap or pop sound, marked weakness, inability to move the affected arm and severe pain.

Study 1:

Collagen peptides were administered daily for 8 weeks and a significant increase in collagen fibril diameter was observed. This indicates that collagen peptides help strengthen the Achilles tendon.

3.2) Preserve Lean Body Mass

Nitrogen balance is the key to muscle growth. Negative nitrogen balance (nitrogen loss is greater than nitrogen intake) destroys muscle, causing its degeneration.

Study 1:

In a double-blind, crossover trial to compare nitrogen balance in elderly women aged 65 to 85. One group had whey protein supplemented to their diet and the experimental group had collagen peptides supplemented to their diet. Results showed that collagen peptides help maintain nitrogen balance and preserve lean body mass.

Skin Health

Aging, exposure to the sun, loss of fatty tissue between the skin and muscle and stress are primary factors contributing to skin aging. It is commonly characterized by visible wrinkling, loss of skin elasticity, laxity, and skin surface roughness. Peptan® Collagen Peptides and Silica-Rx99® helps counteract the effects of aging to promote a youthful appearance by erecting and restructuring the skin’s collagen network from within.

4.1) Reverse the Signs of Aging Skin

By reversing the structural damage of aged skin, Peptan® improves the quantity of skin collagen, which can subsequently help reduce wrinkles, fine lines and restores tone and texture.

Study 1:

In a randomised, placebo-controlled, double-blind clinical trial,106 women aged 40 to 65 received 10g of Peptan® or placebo per day for a period of three months. Results demonstrated stronger collagen structure and firmer skin following Peptan® intake.

4.2) Smoothen Fine Lines and Wrinkles

Fine lines and wrinkles are a natural part of the aging process. With age, the skin becomes thinner, less hydrated and less elastic. This leads to fine lines, creases and wrinkles on the skin. Peptan® Collagen Peptides and Silica-Rx99® can help reduce fine lines and wrinkles, restoring the youthful appearance of healthy skin.

Study 1:

A study was conducted in France to evaluate the effects of oral Peptan® Collagen Peptides on cutaneous properties. 47 women aged 35 to 55 were given 10g of Peptan® powder mixed with liquids for 84 days. They observed significant decrease in the volume and depth of wrinkles.

4.3) Boost Skin Hydration Level

Hydration helps nourish the skin, lessen the appearance of wrinkles and give an overall healthier skin complexion that is supple and smooth. Skin that is not sufficiently hydrated will become dry and flaky, looking dull and rough. Peptan® Collagen Peptides can help replenish the skin’s collagen reserves.

Study 1:

In a randomised, placebo-controlled, double-blind clinical trial, 33 women received 10g of Peptan® or placebo per day for two months. It was found that Peptan® helps counteract skin dryness by increasing the skin’s moisture levels.

4.4) Reduce Visibility of Pores

Aging skin contains less collagen and may result in larger and open pores. Large pores may subsequently increase the likelihood of other skin issues. Especially for those with oily skin, blackheads and acne, may form. Peptan® Collagen Peptides was shown to reduce pore size (visibility), allowing the skin to appear healthy and glowing.

Study 1:

In a randomized, double-blind, placebo-controlled clinical trial, 30 healthy Brazilian women aged 45 to 60 years old received 5g Peptan® Collagen Peptides (bovine) daily for 3 months, and another 30 women received placebo control. Results showed significant improvements in the overall skin complexion. It is characterized by reduced pore visibility in the cheekbone region, reduced appearance of wrinkles around the eyes, nose and mouth, visible increase of the dermis density (contains strength-providing collagen layer of the skin).

Hair and Nail Health

Collagen deficiency can be reflected on the hair and nails. This may include falling hair, breakage and weaker nails. Peptan® Collagen Peptides help strengthen the hair shaft, promote hair and nail growth, and improve the quality to reduce breakage during the lifespan of the hair. It promotes:

• Healthier, stronger and faster-growing hair and nails

• Improved thickness of nails with less splintering

Study 1:

In a randomised, double-blind, placebo-controlled clinical trial, 60 healthy Brazilian women aged 45 to 60 years old received either 5g Peptan® Collagen Peptides or placebo daily for 3 months. Compared to the placebo group, Peptan® supplementation resulted in an increase of the mechanical strength of the hair, which is linked to improved hair cortex. This improvement is especially beneficial for aging hair.